The SUR1 Antibody: Biotin from MyBioSource.com is a Mouse Monoclonal antibody to ABCC8, SUR, and SUR1. This antibody recognizes Mouse, Rat, and Hamster antigen. The SUR1 Antibody: Biotin has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
Background Info: Detects ~160kDa. Does not cross-react with SUR2B
Scientific Background: Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2)